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Search for "drug delivery" in Full Text gives 281 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.
Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems
Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42
- showed good performance in the Franz diffusion test and rodent pharmacokinetic studies due to the nanoparticle size and faster dissolution as compared with the commercial DCS powder. These DCS nanocrystal formulations could offer a new approach for the development of an advanced drug delivery system for
- the treatment of CNS disorders. Keywords: ᴅ-cycloserine; drug delivery system; enteric capsules; N-methyl-ᴅ-aspartate; nanocrystals; NMDA receptor agonist; transdermal reservoir; Introduction Tuberculosis (TB) is a prevalent respiratory disease caused by Mycobacterium tuberculosis. According to the
- ]. Nanocrystals can improve many physicochemical properties of drugs such as solubility, size effect, dissolution rate, and adhesiveness to surface membranes [23]. The limitations of conventional medication delivery can be overcome by advanced drug delivery methodologies, such as transdermal drug delivery (TDD
Classification and application of metal-based nanoantioxidants in medicine and healthcare
Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36
- atherosclerotic plaques [171]. One promising avenue involves the development of metal-based NPs for targeted drug delivery to atherosclerotic lesions. These NPs, often composed of biocompatible metals such as gold, silver, or iron, offer unique properties that enable precise drug delivery to affected areas while
- et al. demonstrated that biodegradable Mg scaffolds have shown promise in promoting vascular regeneration [188]. In brief, the use of metal-based nanomaterials in CVD treatment encompasses a range of innovative approaches from targeted drug delivery using NPs to the development of advanced metallic
Nanomedicines against Chagas disease: a critical review
Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30
- self-nanoemulsified drug delivery systems (SNEDDSs). SNEEDSs provide a pediatric liquid formulation of BNZ, which is only marketed as solid tablets. SNEDDSs are isotropic mixtures of oil, surfactants, and co-surfactants that form submicrometer-droplet emulsions under agitation in water or
- immunosuppression caused by oncological treatments [108]. The big picture shows that nanomedicines, specifically the drug delivery field, are (and probably will be) focused on diseases that exclude parasitic diseases, regardless of their socioeconomic burden. In the next two sections, we will examine the general
- , because of their easy industrial scale-up, structural assessment, and cheaper production (compared to that required for drug delivery or vaccination), could make it to the market against CD. Consider the development of Mosquirix™, which took nearly 35 years, for instance. In comparison, the factors that
Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors
Beilstein J. Nanotechnol. 2024, 15, 297–309, doi:10.3762/bjnano.15.27
- = 0.54) showing the stability and predictive ability of the model. Utilization of the metal oxide cell damage knowledge for cancer treatment NPs have shown immense potential in treating various diseases owing to their small size and high surface-to-volume ratio, which makes them effective drug delivery
Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study
Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24
- drug delivery systems to formulate more effective cancer treatments, thereby addressing the current limitations encountered within this field of study. Functional nanostructures have been designed to mitigate potential harm to healthy tissue caused by these techniques [6]. Additionally, they facilitate
- passive targeting and offer multimodal tumor therapy. In recent years, the use of nanotechnology-based cancer drugs has emerged as a promising alternative treatment approach. Utilizing various nanostructures as specific vehicles for drug delivery enhances efficacy and pharmacokinetic properties of
- anticancer drugs while mitigating the adverse effects of large dosage administration [6][7]. Additionally, it offers several advantages, such as controlled release, targeted drug delivery, and improved stability [8]. Moreover, nanoscale drug delivery systems hold great promise for specific cancer treatments
Ion beam processing of DNA origami nanostructures
Beilstein J. Nanotechnol. 2024, 15, 207–214, doi:10.3762/bjnano.15.20
- DNA origami nanostructures is rarely explored, yet promising applications are foreseen to require such information. DNA nanostructures have been explored as drug delivery vessels for chemotherapeutics [1][2]. With the constant pursuit of effective targeting strategies [3], they could eventually be
Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics
Beilstein J. Nanotechnol. 2024, 15, 180–189, doi:10.3762/bjnano.15.17
- diagnoses, including tumor-targeted drug delivery, hyperthermia, photodynamic therapy, and imaging. Nanomedicines can be made from a variety of inert, biodegradable, and in vivo biocompatible materials. Poly(lactic-co-glycolic acid) is one of the most biodegradable and biocompatible copolymers owing to its
- nanoparticle surfaces would assist the NPs to enter the cells. Therefore, F127 has been used as a nanoparticle component for drug delivery. For example, doxorubicin-loaded L61/F127 NPs (SP1049C, Supratek Pharma Inc., Montreal, Canada) have reached phase three in clinical trials [41][42]. The F127-folate@NP has
Development and characterization of potential larvicidal nanoemulsions against Aedes aegypti
Beilstein J. Nanotechnol. 2024, 15, 104–114, doi:10.3762/bjnano.15.10
- ; drug delivery system; hydrophile–lipophile balance; monoterpenes; Introduction Aedes aegypti (Linnaeus, 1762) is a mosquito species that is cosmopolitan and well adapted to anthropized and peridomestic environments. It is an important vector of arboviruses, including dengue, chikungunya fever, zika
- bioavailability. NEs have been shown to increase the solubility of poorly soluble drugs, such as monoterpenes, which can improve drug delivery and efficacy. The cumulative release of both free terpenes was lower than the cumulative release of nanoemulsions (Figure 2). The observed differences in the release of
Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency
Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7
- cytotoxicity test revealed that the BBR NPs/PLA nanofiber scaffold did not induce any changes in morphology and proliferation of MA-104 cell monolayers. It suggests that the BBR/PLA and BBR NPs/PLA nanofiber scaffolds can be used in different biomedical applications, such as wound dressing, drug delivery
- been employed to produce nanoformulations of drugs for endowing a better therapeutic effect. The nanoformulations for drug delivery can be designed using nanocarrier systems, including organic materials (liposomes, nanoemulsions, nanomicelles, and nanofibers) and inorganic nanoparticles (gold, silver
- polymer solution blended with additional components is applied under a high-voltage electrostatic field, generating a charged and stretched solution jet following nanofiber formation [8][9]. Drug delivery systems based on nanofiber scaffolds produced by electrospinning method have strongly attracted
Influence of conductive carbon and MnCo2O4 on morphological and electrical properties of hydrogels for electrochemical energy conversion
Beilstein J. Nanotechnol. 2024, 15, 57–70, doi:10.3762/bjnano.15.6
- , such as environmental engineering [32], renewable energy [22][33][34][35], electronics [36][37][38], medical devices [39][40][41], and drug delivery systems [42][43][44][45]. They combine the properties of a hydrophilic matrix with conductive properties obtained thanks to the use of an appropriate
Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review
Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4
- solving biopharmaceutical challenges associated with drugs, such as curcumin. From a drug delivery standpoint, nanocarriers (1–1000 nm) can improve stability, increase solubility, promote intracellular delivery, and increase biological activity. Thus, this review offers a deep look into curcumin-loaded
- parasite towards a given drug through decreased uptake of the drug by macrophages [55][56][57]. Thus, nanotechnology-based systems are a promising alternative for drug delivery and vectorization in the treatment of leishmaniasis as they present several advantages. One could mention decreased side effects
- . Nanostructured systems with curcumin for the treatment of leishmaniasis Different nanostructured systems with curc intended for the treatment of leishmaniasis have been developed (Figure 3). The articles included in this work approach the following nanosystems: (i) self-nanoemulsifying drug-delivery systems
Nanotechnological approaches in the treatment of schistosomiasis: an overview
Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2
- nanocarriers to enhance drug delivery by ensuring that drugs are delivered in appropriate amounts to specific target areas and remains in the body for the necessary duration [12]. As a result, nanoparticles have been utilized mainly as drug delivery systems in various parasitic diseases, including
- narrative reviews limited to a specific drug or nanoparticle categories. For instance, some reviews only focus on PZQ [14], while others solely showcase nanosystems for drug delivery [15]. Nonetheless, recent literature reveals several works that employ various drugs and utilize nanoparticles not only as
- S1 (Supporting Information File 1) summarizes all the articles found regarding the use of nanosystems and encapsulated drugs. In Figure 1, it is possible to observe that only 59% of the publications show effectiveness data solely in vivo. Also, most articles use nanoparticles as drug delivery systems
Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells
Beilstein J. Nanotechnol. 2023, 14, 1208–1224, doi:10.3762/bjnano.14.100
- with a fluorescent dye or oxidizing them, as reported by Ma et al. for other PDA NPs [21]. However, the capacity of PDA-based nanoparticles to target and penetrate bacteria for drug delivery, photothermic action, or fluorescent labelling of cells is unknown. Few publications have reported that
Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems
Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95
- Agnes-Valencia Weiss Marc Schneider Department of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, Saarland University, Campus C4 1, Saarbruecken, Germany 10.3762/bjnano.14.95 Abstract Nanoparticles have shown an enormous potential as drug delivery systems in the lab. However
- drug delivery can be achieved, are mechanical properties of nanoparticles. Even though this is often not even considered during formulation development, and it is not requested for approval, an increasing number of studies show that it is important to have knowledge about these characteristics. In this
- properties of drug carriers. Keywords: atomic force microscopy; drug delivery; elasticity; mechanical properties; nanomedicine; nanoparticles; stiffness measurement; tissue/body distribution; Introduction Drug delivery systems are developed with the aim to transport a given drug to the site of action
Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study
Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93
- to confirm the uptake of CUR-HSA-MPs by cancer cells. Our studies revealed that HSA-MPs are potentially promising vehicles for increasing the solubility and bioavailability of CUR. Keywords: albumin submicron particles; cancer therapy; curcumin; drug delivery; Introduction Curcumin (CUR) is a
- carrier of CUR through direct binding [22]. Kar et al. evaluated the affinity of HSA molecules to interact with CUR and reported that the binding constant was about 1.74 × 105 M−1, suggesting a strong interaction [23]. Therefore, albumin can be considered a useful carrier in drug delivery systems for
- . Also, it is seen that, despite the addition of CUR, a typical peanut-like structure was formed by the porous MnCO3 template, as previously found in our studies using the CCD technique [26][27][28][29]. There are strict size requirements for particles in drug delivery systems, typically around 100 nm
Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one
Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85
- arise spontaneously from C3 by hydrolysis, could be considered here. Moghimi et al. report numerous possible interactions of the complement system with, among others, nanoparticles as a drug delivery system [44]. The authors also discussed the possible effects of spontaneously forming water shells and
Upscaling the urea method synthesis of CoAl layered double hydroxides
Beilstein J. Nanotechnol. 2023, 14, 927–938, doi:10.3762/bjnano.14.76
- ]. These materials play a key role both from a fundamental point of view and regarding potential applications in electronic devices, drug delivery, and energy storage and conversion, to name a few [5][6][7][8]. Layered materials range from monoelementals (i.e., graphene, silicene, germanene, or pnictogens
Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics
Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75
- the theranostic applications of ACNPs for the treatment of cancer. Keywords: active targeting; chemical conjugation; chemotherapeutics; drug delivery; monoclonal antibody; Introduction Off-target side effects, such as myelosuppression, mucositis, alopecia, organ dysfunction, and thrombocytopenia
- targeting capabilities [7]. Researchers focused their interest on understanding the obstructions that impede targeted drug delivery, and several advances have been made to develop NPs with enhanced ability to cross these barriers. Bio-pharmacological drugs, which include recombinant proteins, monoclonal
- antibodies (mAbs), and nucleic acid-based materials for targeted drug delivery, have been approved by the Food and Drug Administration (FDA) for the treatment of cancer, arthritis, asthma, psoriasis, pemphigus vulgaris, and chronic urticaria [8]. Antibodies are the primary homing ligands in tumor-targeted
Industrial perspectives for personalized microneedles
Beilstein J. Nanotechnol. 2023, 14, 857–864, doi:10.3762/bjnano.14.70
- medical devices for painless transdermal drug delivery. New and improved additive manufacturing methods enable novel microneedle designs to be realized for preclinical and clinical trial assessments. However, current literature reviews suggest that industrial manufacturers and researchers have focused
- their efforts on one-size-fits-all designs for transdermal drug delivery, regardless of patient demographic and injection site. In this perspective article, we briefly review current microneedle designs, microfabrication methods, and industrialization strategies. We also provide an outlook where
- microneedles may become personalized according to a patient’s demographic in order to increase drug delivery efficiency and reduce healing times for patient-centric care. Keywords: 3D printing; microfabrication; microneedles; personalized medicine; transdermal drug delivery; two-photon polymerization
Silver nanoparticles loaded on lactose/alginate: in situ synthesis, catalytic degradation, and pH-dependent antibacterial activity
Beilstein J. Nanotechnol. 2023, 14, 781–792, doi:10.3762/bjnano.14.64
- of the nanocomposite could be tailored to specific pharmaceutical applications, such as drug delivery, by adjusting the release medium. To investigate the pH-dependent antibacterial effectiveness, zeta potential and morphology of the nanocomposite were examined at pH 4, 6, and 12, as shown in Figure
Nanoarchitectonics for advanced applications in energy, environment and biology: Method for everything in materials science
Beilstein J. Nanotechnol. 2023, 14, 738–740, doi:10.3762/bjnano.14.60
- also discuss coordination-assembled myricetin nanoarchitectonics [32], nanoarchitectonics for membranes with enhanced gas separation capabilities [33], nanoarchitectonics of the cathode of Li–O2 batteries [34], nanoarchitectonics in moist-electric generation [35], nanoarchitectonics for drug delivery
Metal-organic framework-based nanomaterials as opto-electrochemical sensors for the detection of antibiotics and hormones: A review
Beilstein J. Nanotechnol. 2023, 14, 631–673, doi:10.3762/bjnano.14.52
- in MOFs can either be quenched or enhanced. Due to their exceptional characteristics, MOFs have found usage in a variety of fields, including sensors, gas adsorption, energy storage, drug delivery, catalysis, water treatment, and bio-medical imaging [89][90][91][92][93][94][95][96][97][98][99][100
Microneedle patches – the future of drug delivery and vaccination?
Beilstein J. Nanotechnol. 2023, 14, 494–495, doi:10.3762/bjnano.14.40
- diagnostics. Microneedles provide shallow transdermal access to the ISF and are an excellent match to these and other developments when integrated into arrays on a substrate to form a patch. The possibility of inexpensive mass-manufactured MN patches for drug delivery, vaccination, and diagnostic testing is a
- ][9]. Recent progress may be broadly categorised as MN design, fabrication, skin penetration studies, and applications, ranging from drug delivery and vaccination to diagnostics. The first two of these have received most attention, but considerable work is still to be done in all categories – more in
- vaccination and drug delivery, but there is growing evidence of future potential in diagnostics and even in plant science [11]. If the thematic issue helps to inform existing researchers and to encourage others to join them, as editors, we will meet our objectives, the ultimate goal being the acceptance and
New trends in nanobiotechnology
Beilstein J. Nanotechnol. 2023, 14, 377–379, doi:10.3762/bjnano.14.32
- some of the areas of focus in the field known as nanobiotechnology [1]. Nanobiotechnology has a wide array of applications: from organ-on-a-chip technologies to nanobiosensors and nanocatalysts for advanced characterisation and imaging tools, from intelligent drug delivery systems to artificial
Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities
Beilstein J. Nanotechnol. 2023, 14, 362–376, doi:10.3762/bjnano.14.31
- Gram-negative bacteria and Gram-positive bacteria. More specifically, Ch/Q- and Ch/CA-Ag NPs exhibited a bit higher inhibitions against P. aeruginosa. Consequently, such combinations may provide several advantages in targeted drug delivery systems, such as minimal toxicity to normal cells and enhanced
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